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- Introduction to understanding and using RWE
- Sources of real-world data
- Real-world evidence
- Generating real-world evidence
- Summarising and synthesising real-world evidence
- Assuring quality and credibility of RWE
- Modelling effectiveness in the real world
- Adjusting for bias
- Real-world data governance
- Software for evidence synthesis and predictive modelling
- Introduction to developing medicines
- Using the Decision Support Tool
- Clarify the issues
- Background of the efficacy-effectiveness gap
- Toolbox: Methods to generate evidence on effectiveness
- Measuring effectiveness: a review of pre-authorisation RCTs
- Drivers of effectiveness
- Population: effectiveness vs. efficacy
- Intervention: effectiveness vs. efficacy
- Comparator: effectiveness vs. efficacy
- Outcome: effectiveness vs. efficacy
- Patient perspectives in medicines development
- Scientific advice processes
- Existing health technology assessments
- Understand the care pathway/patient journey
- Find RWE options
- Clarify the issues
- GetReal case studies
- Case study: drivers of effectiveness – Hodgkin’s lymphoma
- Case study: drivers of effectiveness – diabetes
- Case study: patient-level drivers of effectiveness – schizophrenia
- Case study: healthcare setting-level drivers of effectiveness – schizophrenia
- Case study: implications of channeling bias – anticoagulant medicines
- Case study: implications of channeling bias-antihypertensive medicines
- Case study: implications of channeling bias – diabetes
- Case study: early pragmatic trials – COPD
- Case study: adjusting for drop out from cmRCTs – CVD
- Case study: modelling/simulation of a population enrichment RCT – schizophrenia
- Case study: methods for NMA using IPD – depression
- Case study: incorporating non-randomised studies in NMA of RCTs – schizophrenia
- Case study: using RWE to connect networks of evidence – rheumatoid arthritis
- Case study: using RWE to estimate relative effectiveness and inform trial design – MS
- Case study: predicting effectiveness based on RCT efficacy data and RWE – rheumatoid arthritis
- Case study: using RWE to inform effectiveness estimates and trial design – metastatic melanoma
- Case study: propensity weighting and extrapolation – non-small-cell lung cancer
- Simulation study: adjusting for bias in a control arm of a pragmatic trial
- Simulation study: comparison of methods for competing risks in pragmatic trials
- Simulation study: controlling for confounding in a pragmatic study with time-to-event outcomes
- Key initiatives
- Policies and Perspectives
- GetReal glossary of terms and definitions
- Terms and conditions
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